Para grandes cálculos renais, outro procedimento minimamente invasivo que também pode ser indicado pelo urologista chama-se de nefrolitotripsia percutânea. Nesse procedimento, um outro instrumento com microcâmera (nefroscópio) é introduzido diretamente no rim através de uma pequena incisão realizada na região lombar do lado acometido. Dessa maneira consegue-se também abordar, fragmentar e remover os cálculos.
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